Welcome to the Institute of Applied Biosciences (IAB)
The Institute of Applied Biosciences was founded in 2005 and consists of seven different departments. The research ranges from bacteria to fungi to food chemistry and toxicology and from basic to applied research.
Biotechnology and Microbial Genetics
The aim of the department of Biotechnology and Microbial Genetics (Prof. Dr. Anne Kaster) is toobtain genomes from new bacterial and archaeal taxa with no sequenced representatives and providing direct link information between cell's phylogenetic and metabolic markers by matching phylogeny and function. We would like to unravel novel metabolisms, ecophysiology and mechanisms of energy conservation among uncultured microorganisms, which were intractable before. In addition, we are investigating minimal genome requirements and syntrophic interactions as well as probing genetic and phenotypic heterogeneity among cells, cell-to-cell variations, horizontal gene transfer and evolutionary pressure.
In the Department of Microbiology (Prof. Dr. Reinhard Fischer) the cell biology and metabolism of filamentous fungi is studied in four areas:
1. In Aspergillus nidulanswe are studying the fungal cytoskeleton and its role in polar growth and discovered a novel microtubule-organizing center at septa.
2. In a second research line we are analyzing the light response of A. nidulans and discovered phytochrome as the red-light sensor protein. We are interested in unraveling the red-light dependent signal transduction processes which control a large propotion of the fungal genome.
3. In Alternaria alternatamycotoxin formation is studied, with a special focus on altertoxins.
4. Recently, we started a new research project with the nematode-trapping fungus Duddingtonia flagransand the nematode Caenorhabditis elegans. We are interested in the signaling processes between the two organisms as well as potential applications of the fungi for biocontrol of nematode-caused plant pests.