Prof. Dr. Reinhard Fischer (born 24.03.1962)
Diplom (Microbiology), University of Marburg, 1987
Ph.D. (Dr. rer. nat.) (Microbiology), University of Marburg, 1990
Postdoc (Microbiology), University of Marburg, 1991
Postdoc (Genetics), University of Georgia, Athens, Georgia, USA, 1992-1993
Research Associate at the Department of Microbiology of the Philipps-University of Marburg and at the Department of Biochemistry of the MPI Marburg, 1994-2004
Habilitation (Microbiology and Cell Biology), University of Marburg, 1998
Professor for Microbiology at the University of Karlsruhe, since 10/2004
Editorial boards: Fungal Genetics and Biology, Molecular Microbiology, FEMS Microbiological Letters, Molecular Genetics and Genomics
Funding: DFG, Landesstiftung Baden Württemberg, Fonds of the Chemical Industry, Humboldt Society, BMBF.
Contact
Karlsruhe Institute of Technology - KIT
Institute for Applied Bioscience
Department of Microbiology
Hertzstraße 16
Geb. 06.40
D-76187 Karlsruhe
Germany
Phone: 49-721-608-44630
Secretary: 49-721-608-44632
Mobile: 49-152-0160-1108
Fax: 49-721-608-54509
e-mail: reinhard fischerIuq6∂kit edu
Members of the Research Group
Ph.D./Diploma students, post docs: Friederike Bathe, Saha Debjani, Ramona Demir, Beatrice Gutt, Maren Hedkte, Christian Kastner, Claudia Kempf, Sylvia Müller, Julia Rodriguez, Sonja Sand, Tanja Sauerbrunn, Tobias Schnuck, Constanze Seidel, Jan Siebenbrock, Norio Takeshita, Nadine Zekert, Julia Zoller
Teaching assistant: Dr. Elisabeth Poth
Technical assistant: Dr. Saturnino Herrero de Vega, Sabrina Hettinger
Secretaries: Fabienne Cochard-Rein, Nihal Yagizefe, Angela Pendl
Research Area: Cell Biology of Aspergillus nidulans
We are studying the filamentous fungus A. nidulans as a model for spore and mycotoxin formation as well as for polarized growth. A. nidulans produces asexual conidiospores for rapid distribution in the environment and sexual ascospores for long-term survival in soil. The decision between the developmental pathways, is determined by a number of environmental factors, one of which is light. Red-light represses sexual and induces asexual reproduction, and the effect can be reversed by far-red-light illumination. Thus, the system is reminiscent of the phytochrome system of plants. Phytochromes are photoreceptors that sense red and far-red light through photo-interconversion between two stable conformations. This distinct feature is mediated by a covalently bound linear tetrapyrrole chromophore. Phytochromes were thought to be confined to photosynthetic organisms including cyanobacteria, but have been recently discovered in heterotrophic bacteria and in fungi, where little is known about their functions. We discovered, that the A. nidulans phytochrome, PhsA, acts as red-light sensor and represses sexual development. We have characterized several other regulators in the past and will now try to link the phytochrome with the regulatory network.
Fungal development is linked to mycotoxin production. This link will be further investigated in A. nidulans at the molecular level.
In a third line of research, we are studying filamentous growth. This growth form enables fungi to extend indefinitely on solid surfaces. They represent a model for extremely polarized eukaryotic cells, similar to neurons in higher eukaryotes. The hyphal cell organisation requires very active intracellular transport. We are analyzing the role of microtubules and microtubule-dependent motor proteins and discovered a role for the kinesin-like motor KipA in microtubule organization.
Recent Publications (complete list)
Zekert, N., Veith, D. & Fischer, R. (2010) Interaction of the Aspergillus nidulans MTOC component ApsB with gamma-tubulin and evidence for a role of a subclass of peroxisomes in the formation of septal MTOCs. Eukaryot. Cell, 9:795-805.
Higashitsuji, Y., Herrero, S., Takeshita, N. & Fischer, R. (2009) The cell end marker protein TeaC is involved in growth directionality and septation in Aspergillus nidulans. Eukaryot. Cell, 8:957-967.
Zekert, N. & Fischer, R. (2009) The Aspergillus nidulans kinesin-3 UncA motor moves vesicles along a subpopulation of microtubules. Mol. Biol. Cell, 20:673-684.
Garzia, A., Etxebeste, O., Fischer, R., Espeso, E.A. & Ugalde, U. (2009) Aspergillus nidulans FlbE is an upstream developmental activator of conidiation functionally associated with the putative transcription factor FlbB. Mol. Microbiol., 71:172-184.
Purschwitz, J., Müller, S. & Fischer, R. (2009) Mapping the interaction sites of Aspergillus nidulans phytochrome FphA with the global regulator VeA and the white-collar protein LreB. Mol. Genet. Genom. 281:35-42.